By Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)
This quantity provides breakthroughs and strategies in affinity capillary electrophoresis to degree and verify the physicochemical and thermodynamic parameters of drug compounds. It discusses techniques to discover and symbolize interactions to facilitate advancements in managed drug supply and concentrating on.
Read Online or Download Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) PDF
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Additional info for Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)
Afﬁnity capillary electrophoresis is an approach where the migration pattern of interacting molecules are used to identify and quantify speciﬁc binding and estimate binding constants. Therefore, the solutes are ﬁrst separated conventionally by CE. In a second run, the run buffer is doped with a speciﬁc complex-forming substance, and the change in the retention time Principles of Capillary Electrophoresis 19 of the solutes is then recorded. Although, formally MEKC can also be considered an ACE method, where hydrophobic or electrostatic interactions between solute and micelle take place, the term ACE generally seems to be more or less conﬁned to stronger and more speciﬁc interactions with welldeﬁned stoichiometry.
5 Calculated mobility with constant [L] at different concentrations of I. 35 36 D. Ru¨ttinger Micellar Electrochromatography With micelles, microemulsions, or liposomes, a second phase is introduced into the separating system. As in chromatography, exchange of the analyte between the mobile and the stationary phases controls the separation process. Contrary to classical chromatography, both phases are mobile, moving with different velocities. As in all electrophoresis techniques, the net mobility of an analyte is the mean mobility of its fraction in the aqueous and the micellar phases: = xaqu и aqu ϩ xmic и mic (45) Introduction of micellar electrochromatography by Terabe and coworkers (18) extended the separation power of capillary electrophoresis to uncharged molecules.
Theoretically, inﬁnite resolution of two peaks could be reached when EOF is equal but opposite to the average mobility u Av. In this case one of the solutes would migrate in the direction of the detector and the other one in the opposite direction. In other words, the separation run would be inﬁnitely long. Thus, for a practical separation the electroosmotic ﬂow should be controlled in a way to achieve baseline resolution (R = 1) at minimal separation time. E. Beneﬁt of Small Capillary Diameters As just mentioned, the application of high voltages is beneﬁcial because efﬁciency and resolution increase with increasing voltage.